LETROZOLE tablet

Find out more about some of the side effects you might have while taking letrozole. If you’re having chemotherapy or radiotherapy, your specialist will tell you when it’s best to start letrozole. Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for.

Possible Side Effects of Letrozole

IUI is when sperm is placed directly into your uterus during your time of ovulation. Letrozole can cause symptoms similar to the menopause such as hot flushes, difficulty sleeping, tiredness and low mood, but these usually improve during the first months of taking it. However, if the symptoms are severe or last longer than a few months, talk to your doctor or breast cancer nurse. Estrogen suppression maintained throughout therapy in patients receiving ≥0.5 mg daily. Patients with cirrhosis and severe hepatic impairment experienced twice the exposure to letrozole as healthy volunteers with normal liver function. These patients should also be treated with a luteinizing hormone-releasing hormone (LHRH) according to current clinical practice standards.

Other side effects

• As BIG 1–98 was initiated at a later time than trials such as ATAC or IES, knowledge of the overall AI side-effect profile also allowed for a more thorough assessment of its safety.
• Cardiovascular events included angina, myocardial infarction, myocardial ischemia, and coronary heart disease.
• The dose of letrozole tablets in patients with cirrhosis and severe hepatic dysfunction should be reduced by 50% see Warnings and Precautions (5.3).
• Whole grains contain more fiber, protein, and micronutrients than refined grains.

More adverse reactions were generally reported in elderly patients irrespective of study treatment allocation. However, in comparison to tamoxifen, no overall differences with regards to the safety and efficacy profiles were observed between elderly patients and younger patients. Letrozole (brand name Femara) is a treatment that may be used to reduce the risk of breast cancer recurrence in postmenopausal women and also to increase the chance of ovulation in women with polycystic ovary syndrome. Side effects include hot flashes, headaches, and joint pain, and it may lower bone mineral density and increase cholesterol levels.

In single-dose studies, the highest dose used was 30 mg, which was well tolerated; in multiple-dosetrials, the largest dose of 10 mg was well tolerated. Comparisons of the incidence of adverse reactions revealed no significant differences between the high and low doseFemara groups in either study. In the extended adjuvant setting (MA-17), based on a median duration of follow-up of 62 months, there was nosignificant difference between Femara and placebo in total cholesterol or in any lipid fraction over 5 years. Use of lipid loweringdrugs or dietary management of elevated lipids was allowed see WARNINGS AND PRECAUTIONS. Femara (letrozole) is a non-steroidal aromatase inhibitor (lowers estrogen production) used to treat breast cancer in postmenopausal women.

Table 13 shows results in the subgroup of women who had received prior antiestrogen adjuvant therapy, Table 14, results by diseasesite and Table 15, the results by receptor status. The Sequential Treatments Analysis (STA) addresses the second primary question of the study. The primary analysis forthe STA was from switch (or equivalent time-point in monotherapy arms) + 30 Pregnyl 5000 Original 5000 IU Organon buy online days (STA-S) with a two-sided testapplied to each pair-wise comparison at the 2.5% level.